Abstract:

The ability of vascular endothelial cells, the cells lining the inner surfaces of blood vessels, to sense and respond to fluid mechanical forces is essential for normal vascular function. Furthermore, abnormalities in endothelial responses to flow play a role in the development of cardiovascular disease. Research over the past two decades has established that when subjected to flow, endothelial cells exhibit numerous humoral, metabolic, and structural responses; however, the mechanisms by which these cells sense flow remain unknown. This talk will present data in support of flow-sensitive ion channels acting as flow sensors in endothelial cells. We will discuss the different types of flow-sensitive ion channels that are present in endothelium, the role of these channels in regulating downstream flow responses, and potential mechanisms by which these channels are activated.