ApplicationofNear4nfrared Spectroscopy to Investigate Brain

Wemara LjChty*a, Kaoru Sakatania Yuxiao Xieb, Huangcong Zu, InOptical Sensing, Imaging, and Manipulation for Biological and Biomedical Applications, Robert R. Alfano, 34 Ping-Pei Ho, Arthur E. T. Chiou, Editors, Proceedings of SPIE Vol. 4082 (2000)

Near infrared spectroscopy has recently been used to measure changes of optical parameters (i.e., light absorption or scattering) ofbrain tissue. The fact that the equipment is generally compact, portable, noninvasive, and reasonably priced makes it ideal for clinical and nondlinical evaluation and monitoring of brain function. Clinical and nonclinical studies evaluating changes related to light absorption are discussed, with an emphasis on cerebral blood oxygenation (CBO) changes and hemodynamic responses while performing cognitive tusks. With respect to the clinical studies, the focus is on variations in patterns of oxygenated hemoglobin (OxyHb), deoxygenated hemoglobin (Deoxy-Hb) and Total4Th (sum of Oxy-Hb and Deoxy4lb). The studies about clinical applications includes research we have conducted with older adults and aphasics. Implications regarding the use ofNIRS for clinical purposes are considered.

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