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Dr. James Chan

Dr. James ChanDr. James Chan is an Assistant Professor in Residence in the Department of Pathology and Laboratory Medicine at University of California, Davis. In addition, he is a Staff Scientist at the NSF Center for Biophotonics Science and Technology  (CBST) at the UC Davis Medical Center in Sacramento, CA.  His research interest broadly encompasses the development of label-free spectroscopic and microscopic techniques for biomedical, biosensing, and chemical sensing applications. Techniques of interest include vibrational spectroscopy (Raman, surface enhanced Raman, coherent anti-Stokes Raman,infrared) and second harmonic generation (SHG) microscopy.

Dr. Chan received his Ph.D. from the Chemical Engineering and Materials Science Dept at UC Davis in 2002, where he used a combination of confocal Raman and fluorescence spectroscopy to investigate the molecular level structural changes in glass induced by tightly focused ultrashort laser pulses. From 2003-2005, he held a postdoctoral appointment at Lawrence Livermore National Laboratory where he applied Raman and CARS spectroscopy for biological and biomedical research. Since 2005, as a Staff Scientist at LLNL, he has been involved with research developing and characterizing novel fiber-based chemical sensors based on vibrational spectroscopy (Raman, IR, SERS) for remote chemical sensing applications while continuing his biophotonics research at CBST.

Research projects in Dr. Chan's lab include the development and biomedical application of the following technologies:

- Single cell laser trapping Raman spectroscopy
- Surface enhanced Raman spectroscopy (SERS)
- Nonlinear microscopy (SHG, CARS)

Current CBST students mentored by Dr. Chan:

- Rui Liu, Biomedical Engineering
- Samir Awasthi, Biomedical Engineering
- Ziliang Mao, Applied Science Program

Selected List of Publications (from the past 3 years):

1.    S. Kim, N. Menegazzo, C. Young, J. Chan, C. Carter, B. Mizaikoff, “Mid-infrared trace gas analysis with single-pass FT-IR hollow waveguide gas sensors,” Applied Spectroscopy, 63, 331-337 (2009)
2.    J.W. Chan, D.K. Lieu, T. Huser, R.A. Li, “Label-free, non-invasive spectroscopic separation of human embryonic stem cells (hESCs) and their cardiac derivatives,” Analytical Chemistry, 81, 1324-1331 (2009)
3.    J.W. Chan, D.K. Lieu, “Label-free biochemical characterization of stem cells using vibrational spectroscopy,” J. Biophotonics, 2, 656-668 (2009)
4.    J.W. Evans, R.J. Zawadzki, R. Liu, J.W. Chan, S.M. Lane, J.S. Werner “Optical coherence tomography and Raman spectroscopy of the ex-vivo retina,” J Biophotonics, 2, 398-406 (2009)
5.    T. J. Moritz, J.A. Brunberg, D.M. Krol, S. Wachsmann-Hogiu, S.M. Lane, J.W. Chan, “Characterisation of FXTAS related isolated intranuclear protein inclusions using laser tweezers Raman spectroscopy,” J. Raman Spectroscopy, 41, 33-39 (2010)
6.    T.J. Moritz, D.S. Taylor, C.R. Polage, D.M. Krol, S.M. Lane, J.W. Chan, “The effect of Cefazolin treatment on the non-resonant Raman signatures of the metabolic states of Escherichia Coli cells,” Analytical Chemistry, 82, 2703-2710 (2010)
7.    M. Bora, B.J. Fasenfest, E.M. Behymer, A.S-P. Chang, H.T. Nugyen, J.A. Britten, C.C. Larson, J.W. Chan, R.R. Miles, T.C. Bond, “Plasmon resonant cavities in vertical nanowire arrays,” Nano Letters, 10, 2832-2837 (2010)
8.    R. Liu, D.S. Taylor, D.L. Matthews, J.W. Chan, “Parallel analysis of individual biological cells using multifocal laser tweezers Raman spectroscopy,” Applied Spectroscopy, 64, 1308-1310 (2010)
9.    T.J. Moritz, C.R. Polage, D.S. Taylor, D.M. Krol, S.M. Lane, J.W. Chan, “Evaluation of Escherichia coli cell response to antibiotic treatment using laser tweezers Raman spectroscopy, Journal of Clinical Microbiology, 48, 4287-4290 (2010)
10.    T.J Moritz, D.S. Taylor, D.M. Krol, J. Fritch, J.W. Chan, “Detection of doxorubicin-induced apoptosis of leukemic T-lymphocytes by laser tweezers Raman spectroscopy,” Biomedical Optics Express, 1, 1138-1147 (2010)
11.    R. Liu, L. Zheng, D.L. Matthews, N. Satake, J.W. Chan, “Power dependent oxygenation state transition of red blood cells in a single beam optical trap,” Applied Physics Letters, 99, 043702-043704 (2011)
12.    S. Awasthi, D.L. Matthews, R.A. Li, N. Chiamvimonvat, D.K. Lieu, J.W. Chan, “Label-free identification and characterization of human pluripotent stem cell-derived cardiomyocytes using second harmonic generation (SHG) microscopy,” J. Biophotonics, 5, 57-66 (2012)


James Chan
NSF Center for Biophotonics
2700 Stockton Blvd., Suite 1400
Sacramento, CA 95817
Phone: 916-734-0774